Per Admin Guide, you must restart the server for the changes in following properties to take effect:
JDBC connection pool properties:
5. JDBC driver vendor-specific properties
Test: Use Admin GUI to change values of above JDBC connection Pool properties:
Resource - JDBC - JDBC Connection Pools - Derby Pool - Advanced
Result: "restart required" is not indicated by Admin CLI/GUI after the changes to these properties are saved.
$ asadmin list-domains
Similar issue: http://java.net/jira/browse/GLASSFISH-15619